ACT Ancillary Studies
Once receiving approval by the ACT Admin Core and Ancillary Study Review Committee, information about ancillary studies is shared to facilitate collaboration on proposed projects and to reduce potential duplication of research on the ACT cohort.
Approved ancillary studies are shared for informational purposes. Investigators who are interested in collaborating with research teams using ACT data can locate grants in the process of being submitted for funding. Interested researchers should contact the lead directly.
TIP: To find an approved ancillary study by month and year, first search by year and then sort by date of approval.
| Submission type | Lead Investigator First Name | Lead Investigator Last Name | Lead Contact Email | Institutional Affiliation | Submission Title | Key Words | Project # | Affiliated ACT Project/Core or Other Related Grant | Date of Approval |
|---|---|---|---|---|---|---|---|---|---|
| Ancillary Study (Type 1) | Helen | Suh | helen.suh@tufts.edu | Tufts University | Airborne Metals, Neurodegeneration and Cognitive Decline: Examining the Olfactory System in The Adult Changes in Thought Study | 242 | 316 | 6/10/2021 | |
| Grant | Mo-Kyung | Sin | sinm@seattleu.edu | Seattle University | Blood pressure, amyloid ? and tau, and cerebral amyloid angiopathy: A pathway for Alzheimer’s dementia management | 251 | N/A | 9/1/2022 | |
| Ancillary Study (Type 1) | Chongzhi | Di | cdi@fredhutch.org | Fred Hutchinson Cancer Research Center | Statistical methods for analyzing objectively measured physical activity data | 255 | N/A | 5/9/2022 | |
| Ancillary Study (Type 2) | John Robert | Warren | warre046@umn.edu | University of Minnesota | Linking ACT to the 1850-1950 U.S. Census | 262 | 262 | 1/27/2023 | |
| Ancillary Study (Type 3) | Cecelia | Lee | leecs2@uw.edu | University of Washington | Aging Eyes and Aging Brains in Studying Alzheimer’s Disease: Modern Ophthalmic Data Collection in the Adult Changes in Thought (ACT) Study (Resubmission) | 268 | P1, EYE ACT | 9/28/2022 | |
| Ancillary Study (Type 1) | James | Andrews | jaandrews@uabmc.edu | University of Alabama Birmingham | Quasi-experimental approaches to determine whether sarcopenia is causally associated with Alzheimer's dementia | 270 | 1/9/2023 | ||
| Ancillary Study (Type 2) | Sarah | Tom | st3144@cumc.columbia.edu | Columbia University | Adult Changes in Thought Occupational Classification and Cognition (ACT-OCC) Study | 275 | 3/10/2023 | ||
| Ancillary Study (Type 3) | Aaron | Seitz | a.seitz@northeastern.edu | Northeastern University | ACT Hear – Digital Technology for Early Detection and Monitoring of Alzheimer’s Disease and Related Dementias | 276 | ACT HEAR | 9/1/2023 | |
| Ancillary Study (Type 1) | Kumar | Rajan | Kumar_Rajan@rush.edu | Rush University Medical Center | Regional and Ethnic Variations in ADRD: A Public Health Outlook | 281 | 6/19/2023 | ||
| Ancillary Study (Type 1) | Magali | Blanco | magali@uw.edu | University of Washington | Traffic-Related Air Pollution and Alzheimer’s Disease and Related Dementia Neuropathologies | 285 | 5/3/2023 | ||
| Ancillary Study (Type 1) | Loki | Natarajan | lnatarajan@ucsd.edu | UCSD | Leveraging deep learning to classify sitting posture and measure sedentary patterns from accelerometer data in diverse cohorts | 293 | 7/26/2023 | ||
| Ancillary Study (Type 2) | Christine | Lary | c.lary@northeastern.edu | Northeastern University | Stronger bones and stronger brains: an epidemiologic study of osteoporosis treatment and risk of Alzheimer’s disease and related dementias (ADRD) | 295 | 9/25/2024 | ||
| Ancillary Study (Type 1) | Ed | Lein | EdL@alleninstitute.org | Allen Institute for Brain Science | A multimodal brain cell atlas and community resource of Alzheimer’s disease and comorbid dementias | 301 | SEA-AD | 9/13/2023 | |
| Ancillary Study (Type 1) | Yue | Lu | yue.lu@pharm.utah.edu | University of Utah | Extracellular Vesicle Profiling: Decoding the Link Between Environmental Toxicant Exposure and Alzheimer's Disease Risk in Population Cohorts | 304 | ACT P2; ACT P3; ACT Life Course Core | 10/16/2023 | |
| Ancillary Study (Type 1) | Danielle | Osborne | dosborne@downeurobiology.org | Legacy Research Institute | Hormonal and obesity influence on Alzheimer's disease etiology via autophagic and lysosomal changes in the hippocampus | 305 | 10/16/2023 | ||
| Ancillary Study (Type 1) | David | Charytan | david.charytan@nyulangone.org | NYU Grossman School of Medicine | Vascular and Alzheimer's related cognitive decline after initiation of maintenance hemodialysis | 306 | 10/16/2023 | ||
| Ancillary Study (Type 1) | Debby | Tsuang | Dwt1@uw.edu | University of Washington/VA Puget Sound | Drug Repurposing for the Prevention of Alzheimer’s Disease and Alzheimer’s Disease Related Disorders | 308 | 2/14/2024 | ||
| Ancillary Study (Type 2) | Pavan | Bhatraju | bhatraju@uw.edu | University of Washington | Cognitive Decline after Acute Kidney Injury (AKI) | 327 | 1/22/2025 | ||
| Ancillary Study (Type 2) | Dori | Rosenberg | Dori.e.rosenberg@kp.org | KPWHRI | The Adult Changes in Thought REsearch on Sleep and Sedentary Time (ACT-RESST) Study: linking to Cardiovascular and Alzheimer’s Disease-related outcomes | 333 | 9/25/2024 | ||
| Ancillary Study (Type 1) | Cecelia | Lee | leecs2@uw.edu | University of Washington | Framingham Heart Study (FHS), Eye ACT and ACT collaborations | A/T/(V)/N framework | 335 | EYE ACT, current U19 | 9/25/2024 |
| Ancillary Study (Type 1) | Shea | Andrews | Shea.andrews@ucsf.edu | UCSF | Evaluating Alzheimer’s disease clinical and polygenic risk scores on the AD phenome in diverse populations | polygenetic risk score, PRS, diversity, clinical risk scores, CRS | 342 | 10/9/2024 | |
| Ancillary Study (Type 2) | Trenton | Honda | t.honda@northeastern.edu | Northeastern University | Air Pollution and Lewy Body Disorders in the Adult Changes in Thought Study | 346 | 316, Airborne metals, neurodegeneration, and dementia in the Adult Changes in Thought study | 10/1/2024 | |
| Ancillary Study (Type 1) | Nicole | Gatto | nicole.m.gatto@kp.org | KPWHRI | Estimated long-term environmental dioxin exposure and cognitive and brain health | 349 | 1/21/2025 | ||
| Ancillary Study (Type 2) | Nicole | Gatto | nicole.m.gatto@kp.org | KPWHRI | Cumulative effects of persistent organic chemical exposure on cognitive decline, Alzheimer’s disease, MRI disease indicators and blood-based biomarkers for ADRD among community-dwelling older adults | 350 | 9/2/2025 | ||
| Ancillary Study (Type 1) | Kristen | Dams-O’Connor | Damsok02@mountsinai.org | Mount Sinai | Leveraging Existing Aging Research Networks to investigate late-life TBI & AD/ADRD (LEARN-TBI-AD) | 362 | 2/11/2025 | ||
| Ancillary Study (Type 2) | Nicole | Gatto | Nicole.M.Gatto@kp.org | KPWHRI | Pilot Study of Persistent Organic Pollutants and Alzheimer's Disease in the Adult Changes in Thought Cohort | 372 | 4/9/2025 | ||
| Ancillary Study (Type 1) | Zachary | Kunicki | zachary_kunicki@brown.edu | Brown University | Acute rehospitalization and cognitive decline/dementia risk | 378 | 8/28/2025 | ||
| Ancillary Study (Type 1) | Magali | Blanco | magali@uw.edu | University of Washington | Traffic-Related Air Pollution and Alzheimer’s Disease and Related Dementia Neuropathologies | 379 | 285 | 5/3/2023 | |
| Ancillary Study (Type 2) | Nicole | Gatto | Nicole.M.Gatto@kp.org | KPWHRI | Impact of plasma concentrations of persistent organic pollutants accumulated over the lifetime on cognitive decline, blood-based biomarkers of Alzheimer’s disease and neurodegeneration, neuroimaging indicators of neurodegeneration, and clinical diagnoses of Alzheimer’s disease and related dementia | 380 | 8/19/2025 | ||
| Ancillary Study (Type 2) | Augusto | Ferraris | aferra@uw.edu | University of Washington | The association between gabapentin use, cognitive trajectories, risk of dementia, and brain structural changes in the Adult Changes in Thought (ACT) study | 381 | 8/11/2025 | ||
| Ancillary Study (Type 2) | Nicole | Gatto | Nicole.M.Gatto@kp.org | KPWHRI | Measured plasma toxic chemical exposure and cognitive decline, dementia, blood-based neurodegeneration biomarkers, and MRI signs of brain atrophy and disease | persistent organic pollutant, PCB, Dioxin, pesticide, PBDE, PFAS, Agent Orange, Alzheimer’s disease, Environment, Cognitive decline, MRI, blood-based biomarker, neurodegeneration, NFL, GFAP, P-tau, beta amyloid, A? | 383 | 7/15/2025 | |
| Ancillary Study (Type 1) | Pamela | Shaw | Pamela.a.shaw@kp.org | KPWHRI | Nonparametric methods to address scientific questions in aging integrating real-world and research databases | 385 | 8/28/2025 | ||
| Ancillary Study (Type 2) | Hong | Li | hogli@health.ucdavis.edu | University of California Davis | Integrated Risk Modeling and Clinical Decision Support for Early Dementia Management | 387 | 9/9/2025 |