Adult Changes in Thought Study

ACT P&P Approved Projects 2026

Once receiving approval by the ACT P&P Committee, information about scholarly works (manuscripts, abstracts, etc.) and data requests leading to scholarly works is shared to facilitate collaboration on active ongoing projects and to reduce potential duplication of research on the ACT cohort. Approved projects are catalogued in searchable tables by year.

Approved data requests and manuscript proposals initiate the formation of writing groups of co-authors. Interested researchers may nominate themselves or a qualified colleague to participate in a writing group by contacting the lead directly. Writing group nominations should occur within the one month following P&P approval.

Approved final draft manuscripts and abstracts are shared for informational purposes. Researchers who are interested in working with ACT data can locate research in the process of being submitted for publication. Once published, manuscripts and abstracts may be found in the ACT Publication Database.

Information on approved projects in 2026
Submission TypeLead Investigator First NameLead Investigator Last NameContact EmailInstitutional AffiliationSubmission TitleKey WordsProject #Affiliated ACT Project/Core or Other Related GrantDate of approvalFinal Decision
Data RequestHeleen Verlindenverlinden@munatherapeutics.comMuna TherapeuticsComprehensive analysis of cellular responses to Alzheimer's and comorbid pathologies with focus on regional, structural, and genetic influencesSpatial transcriptomics Alzheimer's disease399 1/8/2026Approved
Data RequestLindaMcEvoyLinda.k.mcevoy@kp.orgKPWHRIRepurposing Clinically Ordered MRI Structural Images for use in Research on Cognitive Aging: The Adult Changes in Thought StudyVolumetric analysis of clinical scans401ACT U19 Neuroimaging Core1/8/2026Approved
ManuscriptEnna Selmanovicenna.selmanovic@icahn.mssm.eduIcahn School of Medicine at Mount SinaiTraumatic Brain Injury and Late-Life Alzheimer's disease Neuropathology: Quantitative investigation in the Adult Changes in Thought Study 331NP Core1/8/2026Approved
Data RequestErinKulickErin.kulick@temple.eduTemple University Barnett College of Public HealthAssociations between Area-Deprivation Index and Cognitive Function and Declinesocial epidemiology, cognition, SSDoH404ACT U19 Clinical Core; ACT U19 Life Course Core1/8/2026Approved
Data RequestSarahTomst3144@cumc.columbia.eduColumbia UniversityArea Deprivation Index and Incident DementiaSocioeconomic factors, neighborhood405ACT U19 Clinical Core; ACT U19 Life Course Core1/8/2026Approved
Data RequestPamShawPamela.a.shaw@kp.orgKPWHRIConsiderations for the analysis of cognitive scores with Berkson errorBerkson error, bias, cognitive scores, prediction error407ACT research study visit data1/8/2026Approved
AbstractDoriRosenbergdori.e.rosenberg@kp.orgKPWHRIBidirectional Associations Of Physical Activity, Sedentary Behavior, and Sleep and Cognitive Function Among Older Adults 359 2/4/2026Approved
ManuscriptCeciliaLeecslee@wustl.eduWashington University St. LouisAge-related Macular Degeneration Severity and Risk of Alzheimer's Disease in Older Adults in a prospective, community-based cohort studyEyeACT, AMD, dementia297Eye ACT2/4/2026Approved
Data RequestCeciliaLeecslee@wustl.eduWashington University St. Louis/ UWAssociations between Eye Diseases and Occipital Cortex Neuropathologyeye disease, age-related macular degeneration [AMD], diabetic retinopathy [DR], glaucoma, occipital cortex, neuropathology408Eye ACT2/4/2026Approved
Data RequestNuzulul Kurniansyahnkurnia@bu.eduBoston UniversityInfluence of menopausal hormone therapy in women on the association of a multi-ancestry polygenic risk score with Alzheimer disease and related traitsPRS, AD, MHT388Alzheimer's Disease Genetics Consortium Special Analysis Group (SAG)2/4/2026Approved
AbstractLindaMcEvoylinda.k.mcevoy@kp.orgKPWHRIRepurposing Clinically Ordered Structural Magnetic Resonance Images for use in Research on Cognitive Aging: The Adult Changes in Thought Study 401 2/4/2026Approved
Data RequestMichelle CauncaMichelle.Caunca@ucsf.eduUCSFAssociations between Area-Deprivation Index and Neuroimaging Markers of Brain Agingsocial epidemiology, cognition406ACT U19 Clinical Core; ACT U19 Life Course Core2/4/2026Approved
AbstractMina Habibmhhabib@ucla.eduUCLAThe Potential Role of Visual Acuity in the Effect of Age-Related Macular Degeneration on Dementia: A Discrete-Time Causal Mediation and Survival Analysis 297Aim 1c of the Eye ACT Renewal2/4/2026Approved
ManuscriptHeinoHulsey-Vicentnadia@uw.eduUWDigital pathology facilitates 21st century arteriolosclerosis assessment with automated sclerotic index and quantitative perivascular space indices 409NP 2/11/2026Approved
Data RequestSeo-EunChoisc214782@uw.eduUWAssociations between volumetric data from ex vivo imaging and neuropathologyin the ACT autopsy cohortex vivo imaging, neuropathology, elastic net403NP2/4/2026Approved
Data RequestHelenSuhHelen.suh@tufts.eduTufts UniversityAirborne Metals, Neurodegeneration, and Dementia in the ACT Study: PM2.5, Metals and ADRD NeuropathologyPM2.5, metals, neuropathology316APOE, NP data, NDI2/4/2026Approved
ManuscriptLilyShapirolily.x.shapiro@kp.orgKPWHRITraces of dementia experiences in the medical record: Using Natural Language Processing to facilitate qualitative researchProject 2 Aim 3364Project 23/5/2026Approved
ManuscriptLoetCoenenLoet Coenen Biomedical Primate Research CentreMulti-omics characterization of dementia-associated plasma proteins reveal underlying biological signatures and novel neuropathological candidatesneuropathology, APOE257APOE, NP data3/5/2026Approved
ManuscriptRolandHartroland.hart@mountsinai.orgIcahn School of Medicine at Mount SinaiTraumatic Brain Injury and Depressive Symptoms in Aging: A Longitudinal Study 411LEARN TBI 3/5/2026Approved
SAG ProposalShubhabrata (Joey)Mukherjee smukherj@uw.eduUniversity of WashingtonAlzheimer's Disease Genetics Consortium joint dataset 410 3/6/2026Approved
Data RequestKatherinePraterkeprater@uw.eduUniversity of WashingtonLongitudinal Cognition in Neuropathologically Resilient Individualscognition, resilience, Alzheimer's disease389P2 and NP Core 4/1/2026Approved
ManuscriptPattiCurlpcurl@uw.eduUniversity of WashingtonWhite matter hyperintensity variability among cognitively defined Alzheimer's dementia subgroups in a community-based cohortAlzheimer's disease343 4/1/2026Approved
ManuscriptCaitlinLatimercaitlinl@uw.eduUniversity of WashingtonNeuropathologic Features of Cognitively Defined Alzheimer's Disease Subgroups in the Adult Changes in Thought StudyAlzheimer's disease344Project 24/1/2026Approved
ManuscriptLindsayWhitelindsay.white@pennmedicine.upenn.eduUniversity of PennsylvaniaHealth care cost differences across cognitively-defined Alzheimer's disease subgroupsAlzheimer's & Dementia317Project 24/1/2026Approved
ManuscriptPascalGeldsetzerpgeldsetzer@stanford.eduStanford UniversityHerpes Zoster Vaccination and Cognitive Decline: A Quasi-Experimental Study 296 4/13/2026Approved
Data RequestPascalGeldsetzerpgeldsetzer@stanford.eduStanford UniversityAssociation of herpes zoster vaccination and neuroimaging markers in the Adult Changes in Thought (ACT) StudyHerpes zoster, shingles, dementia, cognitive decline, neuroimaging398 5/21/2026Approved
Data RequestAugustoFerrarisaferra@uw.eduUniversity of WashingtonThe association of gabapentin exposure with cognitive trajectories, risk of dementia, and brain structural changes in the Adult Changes in Thought studypharmacoepidemiology; dementia; gabapentin 418 5/21/2026Approved
Data RequestCeceliaLeecslee@wustl.eduUniversity of WashingtonHistorical cognitive trajectories as predictors of current visual acuity and contrast sensitivity in the prospective Eye ACT cohort 417 5/21/2026Approved
Data RequestPascalGeldsetzerpgeldsetzer@stanford.eduStanford UniversityAssociation of herpes zoster episodes and cognitive decline in the Adult Changes in Thought (ACT) StudyHerpes zoster, shingles, dementia, cognitive decline296 6/4/2026Approved
Data RequestCeciliaLeecslee@wustl.eduWashU/University of WashingtonAssociations between Choriocapillaries Flow Deficits and CognitionAMD, visual acuity, dementia, causal inference, causal mediation419Project 1 and Project 26/4/2026Approved
Data RequestMina Habibmhhabib@ucla.eduUCLAThe Potential Role of Visual Acuity in the Effect of Age-Related Macular Degeneration on Dementia: A Causal Mediation and Survival Analysisage-related macular degeneration (AMD), visual acuity (VA), dementia, causal inference, causal mediation420Project 1 and Project 26/4/2026Approved
Data RequestMina Habibmhhabib@ucla.eduUCLAThe Potential Role of Visual Acuity in the Effect of Age-Related Macular Degeneration on Cognitive Function: A Causal Mediation Analysisage-related macular degeneration (AMD), visual acuity (VA), cognitive function, causal inference, causal mediation421Project 1 and Project 26/4/2026Approved
Data RequestWilliamGarciawrgg@uw.eduUniversity of Washington. Department of Global HealthTarget Trial Emulation of Sustained Blood Pressure Reduction and Long-Term Risk of Stroke and Dementia in the ACT Cohortsystolic blood pressure; stroke; dementia422 6/4/2026Approved
Data RequestDominicPadovadpadova1@jhu.eduDepartment of Biomedical Engineering, Johns Hopkins UniversityCortical Morphometry and Cognitive Resilience in Alzheimer's Disease: Analysis of SEA-AD Postmortem and Antemortem Structural MRIcognitive resilience, cortical morphometry, Alzheimer's disease423 6/4/2026Approved
ManuscriptNicoleGattonicole.m.gatto@kp.orgKPWHRIImproving representation of participants in prospective studies of brain health: the Adult Changes in Thought study experienceAlzheimer's309 6/4/2026Approved
ManuscriptMagaliBlancomagali@uw.eduUniversity of WashingtonAir Pollution Mixture Exposure and Alzheimers Disease and Related Dementia Neuropathologies in a Community-Based Cohort 285 6/4/2026Approved
Data RequestCeciliaLeecslee@wustl.eduWashU/University of WashingtonAge and eye disease effects on visual acuityOphthalmology, eye health, aging424EYE ACT 7/2/2026Approved
ManuscriptJanelleTaylorjanelle.taylor@utoronto.caUniversity of TorontoDementia Care Through the Portal: A Qualitative Analysis of Secure Messages Sent by Older Adults and Their Family Members 426P2 AIM 37/28/2026Approved
ManuscriptPamShawPamela.A.Shaw@kp.orgKPWHRIAssociation of physical activity, sedentary time, and sleep (the 24-hour activity cycle) with cognitive and physical function trajectories in the Adult Changes of Thought (ACT) study of older adults 359P18/6/2026Approved
ManuscriptSarahTomst3144@cumc.columbia.eduColumbia UniversityLiving arrangement and cognitive function among older adults in the Adult Changes in Thought Study 328LC Core 8/6/2026Approved
Data RequestNicoleGattoNicole.M.Gatto@kp.orgKPWHRIAn Eye Feature-based Scoring System for Diabetic Retinopathy Severity and Risk of Alzheimer's Disease and Dementia among Community-Dwelling Older Adultsdiabetic retinopathy, diabetes, dementia, Alzheimer's disease, item-response theory, severity, severity score 428EYE ACT9/17/2026Approved
AbstractChloeKrakauerchloe.a.krakauer@kp.orgKPWHRIMaking coarsened data continuous again: results from the comparison of methods to assess associations between living arrangements and cognition among the elderly 374LC Core 9/17/2026Approved