ACT P&P Approved Projects 2025
Once receiving approval by the ACT P&P Committee, information about scholarly works (manuscripts, abstracts, etc.) and data requests leading to scholarly works is shared to facilitate collaboration on active ongoing projects and to reduce potential duplication of research on the ACT cohort. Approved projects are catalogued in searchable tables by year.
Approved data requests and manuscript proposals initiate the formation of writing groups of co-authors. Interested researchers may nominate themselves or a qualified colleague to participate in a writing group by contacting the lead directly. Writing group nominations should occur within the one month following P&P approval.
Approved final draft manuscripts and abstracts are shared for informational purposes. Researchers who are interested in working with ACT data can locate research in the process of being submitted for publication. Once published, manuscripts and abstracts may be found in the ACT Publication Database.
| Submission Type | Lead Investigator First Name | Lead Investigator Last Name | Contact Email | Institutional Affiliation | Submission Title | Key Words | Project # | Affiliated ACT Project/Core or Other Related Grant | Date of Approval |
|---|---|---|---|---|---|---|---|---|---|
| Manuscript | Mikael Anne | Greenwood-Hickman | mikael.anne.greenwood-hickman@kp.org | KPWHRI | Associations Between 10-year Physical Performance and Activities of Daily Living Trajectories with Physical Behaviors in Older Adults | physical activity, sedentary behavior, sitting, sleep | 319 | 1/8/2025 | |
| Data Request | Sarah | Tom | st3144@cumc.columbia.edu | Columbia University | Internet use and cognition in the Adult Changes in Thought Study | internet use, cognition, older adults | 360 | ACT Life Course Core | 1/8/2025 |
| Data Request | Katrina | Bazemore | bazemork@pennmedicine.upenn.edu | University of Pennsylvania | Polygenic Risk Scores for Probable Alzheimer’s Disease (AD)- Related Dementias Genome-Wide Association Studies by Proxy (GWAX) | AD PRS Informed GWAX | 361 | 5/1/2025 | |
| Abstract | Willa | Brenowitz | Willa.D.Brenowitz@kpchr.org | Kaiser Permanente Center for Health Research | Associations of hearing loss and hearing aid use with brain pathologies at autopsy in a community-based cohort | 241 | 1/28/2025 | ||
| Abstract | Lily | Shapiro | Lily.X.Shapiro@kp.org | KPWHRI | Dementia Caregiving and the Limits of Biomedicine: Navigating Bureaucracy and Developing Expertise | 363 | ACT P2 | 2/13/2025 | |
| Abstract | Lily | Shapiro | Lily.X.Shapiro@kp.org | KPWHRI | Using qualitative analysis of secure messages to explore the experience of patients with dementia and their caregivers | 364 | ACT P2 | 2/13/2025 | |
| Data Request | Shelly | Gray | slgray@uw.edu | University of Washington | CNS-active medications and association with sedentary time and physical activity in older adults | CNS-active medications, sedentary time, physical activity | 365 | ACT P1 | 3/6/2025 |
| Abstract | Patti | Curl | pcurl@uw.edu | University of Washington | Cognitively-defined AD dementia subgroups have different MRI white matter hyperintensity distribution in a community-based cohort | AAIC 2025 | 343 | ACT P2 | 3/6/2025 |
| Data Request | Magali | Blanco | magali@uw.edu | University of Washington | Heterogeneity in the effect of APOE on dementia risk | APOE, dementia, effect modifiers, causal inference | 336 | 3/6/2025 | |
| Data Request | Helen | Suh | Helen.suh@tufts.edu | Tufts University | Airborne metals, neurodegeneration, and dementia in the Adult Changes in Thought study | air pollution, cognitive trajectories, dementia | 366 | 316 | 3/6/2025 |
| Data Request | Isaac | Crane | icrane@uchicago.edu | University of Chicago | Associations between accelerated brain aging, multiple MRI modalities, and AD-related and vascular disease related genetic risk scores | accelerated brain aging (structural MRI), functional connectivity, genetic risk scores | 348 | 4/3/2025 | |
| Data Request | Ariel | Rokem | arokem@uw.edu | University of Washington | Associations between blood glucose levels, white matter tissue properties, and cognitive profiles in aging | White matter, Glucose, Aging | 356 | ACT P2 | 5/1/2025 |
| Abstract | Caitlin | Latimer | caitlinl@uw.edu | University of Washington | Cognitively defined AD dementia subgroups have different neuropathology findings in a community-based autopsy cohort | AAIC 2025 | 369 | ACT Neuropathology Core | 4/3/2025 |
| Abstract | Joshua | Russell | University of Washington | Development of an automated pipeline for systematically quantifying brain arteriolosclerosis from postmortem tissue | AAIC 2025 | 370 | 4/3/2025 | ||
| Manuscript | Shelly | Gray | slgray@uw.edu | University of Washington | Cumulative anticholinergic exposure and change in gait speed and grip strength in older adults | Aged, gait speed, hand strength, anticholinergic medications | 218 | 218 | 4/3/2025 |
| Abstract | Sarah | Tom | st3144@cumc.columbia.edu | Columbia University | Internet Use and Cognition in Older Adults | APHA | 360 | ACT Life Course Core | 5/1/2025 |
| Data Request | Chloe | Krakauer | chloe.a.krakauer@kp.org | KPWHRI | Living Arrangement and Cognition: Approaches to Analyzing Interval-Censored Data in ACT | Living arrangement, cognition, interval-censored | 374 | ACT Life Course Core | 5/1/2025 |
| Data Request | Michelle | Caunca | Michelle.Caunca@ucsf.edu | UCSF | Associations between Individual-Level Property Value and Cognitive Function | social epidemiology, cognition | 368 | ACT Life Course Core | 5/1/2025 |
| Data Request | Nadia | Postupna | nadia@uw.edu | University of Washington | Development of an automated pipeline for systematically quantifying brain arteriolosclerosis from postmortem tissue | Arteriolosclerosis, Digital neuropathology | 375 | ACT Neuropathology Core | 6/5/2025 |
| Data Request | Keith | Cole | Keith.cole@vumc.org | Vanderbilt University Medical Center | The relationship between free-living gait and cognition | Gait, Cognition, Mobility | 376 | 6/5/2025 | |
| Data Request | Ed | Lein | EdL@alleninstitute.org | Allen Institute for Brain Science | A platform for cell type-level transcriptomics, epigenomic and spatial interrogation of AD (Human AD Center - Allen U19) | 245 | Allen U19 SEA-AD | 6/5/2025 | |
| Data Request | LaShae | Nicholson | lashae.nicholson@yale.edu | Yale University | Impact of impaired glucose metabolism on AD progression | Diabetes, Alzheimer’s, Inhibitory Neurons | 373 | 6/5/2025 | |
| Manuscript | Janelle | Taylor | janelle.taylor@utoronto.ca | University of Toronto | The Matter of Hospitals: An Alphabetical Investigation - Records | 377 | ACT P2 | 6/5/2025 | |
| Abstract | Chloe | Krakauer | chloe.a.krakauer@kp.org | KPWHRI | Comparing Regression Coefficient Estimators with Interval-Censored Exposure Data | Living arrangement, cognition, interval-censored | 374 | ACT Life Course Core | 7/3/2025 |
| Data Request | Cecilia | Lee | leecs2@uw.edu | University of Washington | Exploring the Link Between Eye Disease History and Brain Health in Older Adults | eye disease, age related macular degeneration [AMD], diabetic retinopathy [DR], glaucoma, MRI, brain volume, white matter hyperintensities, cognitive function | 382 | Eye ACT, 358 | 7/3/2025 |
| Data Request | Shelly | Gray | slgray@uw.edu | University of Washington | Adult Changes in Thought (ACT) U19 Project 3: Translational Pharmacoepidemiology - Data Only | Antihypertensives, neuroimaging outcomes, neurodegeneration | 384 | ACT P3 | 8/6/2025 |
| Data Request | Ariel | Rokem | arokem@uw.edu | University of Washington | Anatomy-implied blood vessel morphology and its relation to adult changes in thought | Brain, deep learning, vasculature | 386 | ACT P2 | 8/22/2025 |
| Data Request | Katherine | Prater | keprater@uw.edu | University of Washington | Identifying microglia subpopulations associated with resilience to Alzheimer’s Disease cognitive decline | microglia, resilience, Alzheimer’s disease | 389 | ACT Neuropathology Core | 9/4/2025 |
| Data Request | Sarah | Tom | st3144@cumc.columbia.edu | Columbia University | Early life environment and later-life neuropathological outcomes related to Alzheimer’s Disease | social determinants, neuropathology, life course | 390 | ACT Life Course Core & ACT Neuropathology Core | 9/4/2025 |