ACT P&P Approved Projects 2026
Once receiving approval by the ACT P&P Committee, information about scholarly works (manuscripts, abstracts, etc.) and data requests leading to scholarly works is shared to facilitate collaboration on active ongoing projects and to reduce potential duplication of research on the ACT cohort. Approved projects are catalogued in searchable tables by year.
Approved data requests and manuscript proposals initiate the formation of writing groups of co-authors. Interested researchers may nominate themselves or a qualified colleague to participate in a writing group by contacting the lead directly. Writing group nominations should occur within the one month following P&P approval.
Approved final draft manuscripts and abstracts are shared for informational purposes. Researchers who are interested in working with ACT data can locate research in the process of being submitted for publication. Once published, manuscripts and abstracts may be found in the ACT Publication Database.
| Submission Type | Lead Investigator First Name | Lead Investigator Last Name | Contact Email | Institutional Affiliation | Submission Title | Key Words | Project # | Affiliated ACT Project/Core or Other Related Grant | Date of approval |
|---|---|---|---|---|---|---|---|---|---|
| Data Request | Heleen | Verlinden | verlinden@munatherapeutics.com | Muna Therapeutics | Comprehensive analysis of cellular responses to Alzheimer's and comorbid pathologies with focus on regional, structural, and genetic influences | Spatial transcriptomics Alzheimer's disease | 399 | 1/8/2026 | |
| Data Request | Linda | McEvoy | Linda.k.mcevoy@kp.org | KPWHRI | Repurposing Clinically Ordered MRI Structural Images for use in Research on Cognitive Aging: The Adult Changes in Thought Study | Volumetric analysis of clinical scans | 401 | ACT U19 Neuroimaging Core | 1/8/2026 |
| Manuscript | Enna | Selmanovic | enna.selmanovic@icahn.mssm.edu | Icahn School of Medicine at Mount Sinai | Traumatic Brain Injury and Late-Life Alzheimer's disease Neuropathology: Quantitative investigation in the Adult Changes in Thought Study | 331 | NP Core | 1/8/2026 | |
| Data Request | Erin | Kulick | Erin.kulick@temple.edu | Temple University Barnett College of Public Health | Associations between Area-Deprivation Index and Cognitive Function and Decline | social epidemiology, cognition, SSDoH | 404 | ACT U19 Clinical Core; ACT U19 Life Course Core | 1/8/2026 |
| Data Request | Sarah | Tom | st3144@cumc.columbia.edu | Columbia University | Area Deprivation Index and Incident Dementia | Socioeconomic factors, neighborhood, | 405 | ACT U19 Clinical Core; ACT U19 Life Course Core | 1/8/2026 |
| Data Request | Michelle | Caunca | Michelle.Caunca@ucsf.edu | UCSF | Associations between Area-Deprivation Index and Neuroimaging Markers of Brain Aging | social epidemiology, cognition | 406 | ACT U19 Clinical Core; ACT U19 Life Course Core | 1/8/2026 |
| Data Request | Pam | Shaw | Pamela.a.shaw@kp.org | KPWHRI | Considerations for the analysis of cognitive scores with Berkson error | Berkson error, bias, cognitive scores, prediction error | 407 | ACT research study visit data | 1/8/2026 |
| Abstract | Dori | Rosenberg | dori.e.rosenberg@kp.org | KPWHRI | Bidirectional Associations Of Physical Activity, Sedentary Behavior, and Sleep and Cognitive Function Among Older Adults | 359 | 2/4/2026 | ||
| Manuscript | Cecilia | Lee | cslee@wustl.edu | Washington University St. Louis | Age-related Macular Degeneration Severity and Risk of Alzheimer's Disease in Older Adults in a prospective, community-based cohort study | EyeACT, AMD, dementia | 297 | Eye ACT | 2/4/2026 |
| Data Request | Cecilia | Lee | cslee@wustl.edu | Washington University St. Louis/ UW | Associations between Eye Diseases and Occipital Cortex Neuropathology | eye disease, age-related macular degeneration [AMD], diabetic retinopathy [DR], glaucoma, occipital cortex, neuropathology | 408 | Eye ACT | 2/4/2026 |
| Data Request | Nuzulul | Kurniansyah | nkurnia@bu.edu | Boston University | Influence of menopausal hormone therapy in women on the association of a multi-ancestry polygenic risk score with Alzheimer disease and related traits | PRS, AD, MHT | 388 | Alzheimer's Disease Genetics Consortium Special Analysis Group (SAG) | 2/4/2026 |
| Abstract | Linda | McEvoy | linda.k.mcevoy@kp.org | KPWHRI | Repurposing Clinically Ordered Structural Magnetic Resonance Images for use in Research on Cognitive Aging: The Adult Changes in Thought Study | 401 | 2/4/2026 | ||
| Data Request | Michelle | Caunca | Michelle.Caunca@ucsf.edu | UCSF | Associations between Area-Deprivation Index and Neuroimaging Markers of Brain Aging | social epidemiology, cognition | 406 | ACT U19 Clinical Core; ACT U19 Life Course Core | 2/4/2026 |
| Abstract | Mina | Habib | mhhabib@ucla.edu | UCLA | The Potential Role of Visual Acuity in the Effect of Age-Related Macular Degeneration on Dementia: A Discrete-Time Causal Mediation and Survival Analysis | 297 | Aim 1c of the Eye ACT Renewal | 2/4/2026 | |
| Manuscript | Heino | Hulsey-Vicent | nadia@uw.edu | UW | Digital pathology facilitates 21st century arteriolosclerosis assessment with automated sclerotic index and quantitative perivascular space indices | 409 | NP | 2/11/2026 | |
| Data Request | Seo-Eun | Choi | sc214782@uw.edu | UW | Associations between volumetric data from ex vivo imaging and neuropathologyin the ACT autopsy cohort | ex vivo imaging, neuropathology, elastic net | 403 | NP | 2/4/2026 |
| Data Request | Helen | Suh | Helen.suh@tufts.edu | Tufts University | Airborne Metals, Neurodegeneration, and Dementia in the ACT Study: PM2.5, Metals and ADRD Neuropathology | PM2.5, metals, neuropathology | 316 | APOE, NP data, NDI | 2/4/2026 |