Adult Changes in Thought Study

Neuroimaging Data

Neuroimaging Data.png Data Description

Processed measures from brain magnetic resonance imaging (MRI) exist for some participants in the Adult Changes in Thought (ACT) Study. These measures, provided by the ACT Neuroimaging Core, come from a mix of clinical MRI scans that were abstracted from medical records of consenting ACT participants and research MRI scans that were conducted among select samples of participants.

Study Forms

Not applicable. Because these data elements are derived directly from neuroimaging scans and radiologists’ interpretation, no forms are used to collect these data from participants.

Key Publications

The following publications provide additional detail on the neuroimaging data elements. These may be helpful supporting citations when publishing analyses using these data.

  • Mossa-Basha M, Andre JB, Yuh E, Hunt D, LaPiana N, Howlett B, Krakauer C, Crane P, Nelson J, DeZelar M, Meyers K, Larson E, Ralston J, Mac Donald CL. Comparison of brain imaging and physical health between research and clinical neuroimaging cohorts of ageing. Br J Radiol. 2024 Feb 28;97(1155):614-621. doi: 10.1093/bjr/tqae004. PMID: 38303547; PMCID: PMC11027291.
  • Li KH, Krakauer C, Nelson JC, Crane PK, Andre JB, Curl PK, Yuh E, Mossa-Basha M, Ralston JD, Mac Donald CL, Gray SL. Cumulative anticholinergic exposure and white matter hyperintensity burden in community-dwelling older adults. J Am Geriatr Soc. 2025 Apr;73(4):1115-1124. doi: 10.1111/jgs.19325. Epub 2024 Dec 19. PMID: 39697086; PMCID: PMC11971017.
  • Chang K, Burke L, LaPiana N, Howlett B, Hunt D, Dezelar M, Andre JB, Curl P, Ralston JD, Rokem A, Mac Donald CL. Free water elimination tractometry for aging brains. Imaging Neurosci (Camb). 2025 Nov 7;3:IMAG.a.991. doi: 10.1162/IMAG.a.991. PMID: 41230414; PMCID: PMC12603662.

Data Dictionary

A data dictionary is available to provide additional information about ACT data variables.